CiBER-seq yields comprehensive and quantitative profiles of transcriptional, translational, or post-translational regulatory responses across genome-scale CRISPR perturbation libraries. We can imagine a lot of uses for CiBER-seq and we look forward to seeing how it's used!
Proximity labeling by the APEX enzyme can directly tag nearby RNA in cells with biotin, providing insight into the localization and organization of RNA. Our bioRχiv pre-print is still available.
Mia found that eIF3 provides another layer of translational control over ferritin light chain mRNA, on top of the well-studied effects of iron regulatory protein (IRP), and linked this regulation to some human hyperferritinemia mutations.
We're excited to see what others do with the turbidostat and we'll be sharing some of our own work soon!
We were excited to work with Ron Kopito's lab to learn more about how and why the ubiquitin-like modifier UFM1 is conjugated to RPL26 on ER-associated ribosomes.
Shintaro began this work in the Ingolia lab and finished it in his own lab at RIKEN in collabration with his colleague there, Takuhiro Ito. It's exciting to see how RocA produces sequence-specific translational inhibition through direct drug-RNA contacts.
Proximity labeling by the APEX enzyme can directly tag nearby RNA in cells with biotin, providing insight into the localization and organization of RNA.
Rachel is a student in the MCB program, who comes here from NYU.
Wren comes to us after completing a Ph.D. in Cellular and Molecular Physiology from Johns Hopkins, where he worked in the Dawson lab on LRRK2 in Parkinson's
Paige is a student in the MCB program who joins us after graduating from Drake University.
Sam comes to us from UCSF, where she worked after undergraduate studies at Berkeley. Ryan joins us after graduating from ASU, and was an Amgen Scholar at Berkeley one summer.